Malaria, the mosquito-borne infectious disease caused by Plasmodium parasites, has been successfully eliminated or significantly reduced in many regions of the world, but remains widespread in others. Most of Europe, North America, Australia, North Africa and the Caribbean, along with parts of South America, Asia and Southern Africa, are now free from malaria, while much of the central part of Africa continues to experience high levels of transmission. The World Health Organization (WHO) defines "elimination" (or "malaria-free") as having no domestic transmission (indigenous cases) for the past three years.

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